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USMLE Vault · Step 1 · Musculoskeletal

MSK, Start to Finish, in 6 Days

35 First Aid pages · 7 organisms · 6 days · no dermatology. The week most IMGs lose to 1 mistake.

By Dr. Marish Asudani · Published

How do I study MSK for Step 1 in 6 days?

Leave dermatology out and do it separately. Day 1: the 7 MSK organisms. Day 2 to the middle of Day 3: active reading of First Aid pp. 450–480 and 495–498 on the First Aid Guide, with the MCQs on every page. Then the Mehlman Medical MSK playlist, then the FA Foundation Anki MSK cards. Days 5–6: UWorld MSK, system-wise, with the RPSR method, aiming for 65% or above.

Read this first. This plan is only for you if you have roughly 10–12 hours a day for studying, and you're either an intern or a graduate. Working, with 5–8 hours a day? Keep the same order and stretch the days: Step 1 while working →

MSK is usually done badly for 1 simple reason. Students open the MSK chapter, find dermatology at the end of it, and try to do both at once. 2 different subjects, 1 week, and neither of them sticks.

So the first rule is this: MSK is done without dermatology. The derm block comes after MSK is finished.

Everything else is the method I use for every system, and every step hits the same 35 pages from a different angle. The whole method, once: how to study any system.

▶How to Do the MSK/Derm System15 minutes. Watch it once, before Day 1. It's the same video the Vault schedule gives you on day 1 of MSK.
Start here · before page 1

MSK: micro and pharm first

MSK starts with its own organisms: 7 organisms, without derm. MSK has no Pharm pill, because the drug map does not split out MSK drugs, so its pharm is a check of the High-Yield Pharmacology PDF on Day 1 and the drug pages (pp. 495–498) on Day 2. These are the full guides.

Microbiology Pharmacology
Where this system sits

The order: easy systems first, cardio last

MSK is the 8th system. It opens the neuro block: MSK, then derm, then psychiatry, then genetics and ANS, then neurology. Cardio comes last. Tap a system to open its guide.

  1. 1Renal6 days · the easy one, start hereOpen →
  2. 2Respiratory6 days · same method as renalOpen →
  3. Before it: Biochem nutrition, 1 day, right before GI · where it sits
  4. 3GI7 daysOpen →
  5. 4Reproductive7 daysOpen →
  6. Before it: Biochem carb and lipid metabolism, 1 day, right before endo · where it sits
  7. 5Endocrine6 daysOpen →
  8. 6Immunology5 daysOpen →
  9. Before it: Biochem cellular, molecular and amino acids, right before heme-onc · where it sits
  10. 7Heme-onc6 daysOpen →
  11. 8MSK You are here6 days, no dermOpen →
  12. Before it: Dermatology, 3 days, after MSK · the derm block
  13. 9Psychiatry5 daysOpen →
  14. Before it: Genetics and ANS, right before neuro · genetics
  15. 10Neurology7 daysOpen →
  16. 11Cardiovascular7 days · always lastOpen →

Biochem is never a block of its own: each piece sits right before the system that needs it. The whole method, once: how to study any system →

MSK in 6 days, hour by hour

One fixed order. The organisms first, then active reading, then active application, then active recall, and only then UWorld.

Clock times assume an 11-hour day: 9 AM–1 PM, 2–6 PM and 7–10 PM, with lunch and dinner in the gaps. Shift the clock to your day. Keep the order.

Day 1 · Micro + the pharm checkThe lightest day of the week: 7 organisms
9–9:15 AMWatch How to Do the MSK/Derm System, the University walkthrough.
9:15 AM–1 PMMicro: the 7 MSK organisms, WRWRT. Watch, recall, watch the gaps, read the Sketchy PDF, then the First Aid Guide MCQs for all 7.
2–3 PMPharm: open the High-Yield Pharmacology PDF and find any MSK drugs. Any notes there, you do next to pp. 495–498 on Day 3.
3–6 PMRest, or get ahead on pp. 450–454.
Day 2 · Active readingFirst Aid Guide, page by page, MCQs on every page
9 AM–1 PMpp. 450–458 · upper and lower limb nerves, rotator cuff, brachial plexus, hand, hip and knee, radiculopathy
2–6 PMpp. 459–467 · muscle contraction, fibre types, bone formation and cells, sports injuries, childhood MSK conditions, achondroplasia, osteoporosis
7–10 PMpp. 468–475 · osteopetrosis, osteomalacia, Paget, avascular necrosis, bone tumours, OA vs RA, gout, Sjögren, septic arthritis, spondyloarthritis
Day 3 · Reading, then MehlmanSkip pp. 481–494: that's derm
9 AM–1 PMpp. 476–480 and 495–498 · lupus, myositis, the vasculitides, NMJ diseases, Raynaud, then the MSK drugs
2–6 PMWatch How to watch Mehlman Medical videos (10 minutes), then the Mehlman anatomy and MSK playlist from the top, in order.
7–10 PMMehlman, continued. Pause before he answers and answer it yourself.
Day 4 · Mehlman, then Anki
9 AM–1 PMFinish the Mehlman MSK playlist. Any gap → that First Aid Guide page, the same day.
2–6 PMFA Foundation Anki · MSK, all 136 cards. The derm cards in it are an early pass. Answer before you flip.
7–9 PMOpen the First Aid page of every card you hesitated on. Read the line and a couple above and below.
Day 5 · UWorld MSKUnused · musculoskeletal only · tutor mode · 20 questions a block
9–9:30 AMClear today's due FA Foundation Anki cards first.
9:30 AM–1 PMBlocks 1–2 (Qs 1–40): solve both in tutor mode, log each score, then review every bookmark in First Aid.
2–6 PMBlocks 3–4 (Qs 41–80): solve both in tutor mode, log each score, then review every bookmark in First Aid.
7–10 PMBlocks 5–6 (Qs 81–120): solve both in tutor mode, log each score, then review every bookmark in First Aid.
Day 6 · UWorld MSK + the finish checkBlocks 13–14 go to the next morning, before derm
9–9:30 AMClear today's due FA Foundation Anki cards first.
9:30 AM–1 PMBlocks 7–8 (Qs 121–160): solve both in tutor mode, log each score, then review every bookmark in First Aid.
2–6 PMBlocks 9–10 (Qs 161–200): solve both in tutor mode, log each score, then review every bookmark in First Aid.
7–10 PMBlocks 11–12 (Qs 201–240): solve both in tutor mode, log each score, then review every bookmark in First Aid.

Want a day-by-day schedule that tells you exactly what to study next? The Vault builds it around your exam date.

USMLE Vault day-by-day schedule Build my schedule →
Day 1

Micro of MSK, from the pill

Open the First Aid Guide → MSK in the Vault (what the First Aid Guide is) and tap the Micro pill. It opens the exact MSK list and nothing else. There are only 7 organisms, so Day 1 is the lightest day of the week. Use what's left of it to rest, or to start the Day 2 pages early.

Open MSK in the First Aid GuideFirst Aid pp. 450–480 and 495–498, page by page: Focus On, ELI5 and the MCQs on every page. Opens straight into MSK.

Open MSK →
🦠
Micro · 7 organisms · the WRWRT method. Watch the sketch at 1x with no notes → Recall the whole story in your head, in order → Watch again only the gaps at 1.5–1.75x → Read the Sketchy PDF for that organism → Test with the First Aid Guide MCQs for that organism.
01 · Gonococci 02 · Borrelia 03 · Staphylococcus 04 · Salmonella 05 · Parvovirus 06 · Rubella 07 · Coccidioides
Open MSK Micro → ▶How to Do Sketchy MicroThe WRWRT method on video. Watch once if you've never done Sketchy this way.
💊
Pharm · no separate list for MSK. The pharm map has no MSK row, so there is no pharm video block today. Before you read, open the High-Yield Pharmacology PDF and look for any MSK drugs; if there are notes, do them next to the drug pages. The MSK drugs live on First Aid pp. 495–498 (acetaminophen, aspirin and NSAIDs, bisphosphonates, gout drugs, teriparatide, TNF-α inhibitors and the biologics), and you read them on Day 3 like any other page.
Why micro first: when you reach septic arthritis and osteomyelitis on p. 474, you meet the organisms as old friends, not new facts. Never done Sketchy? Do the same 7 from First Aid and the First Aid Guide alone. The list does not change, only the source.

Before Day 2: what the First Aid Guide is

First Aid was written to remind you, not to teach you. The First Aid Guide puts the teaching back into every page: Focus On (what's high-yield and what to skip), a Concept Walkthrough, an ELI5 for each heading, How is this tested?, and the Test Yourself MCQs for that exact page. MSK without derm carries 145 MCQs (as of October 2026).

This is what a real MSK page opens with. Page 450, upper extremity nerves, Focus On:

Focus On, p. 450: "The key here is understanding which nerve controls what function and where each nerve is vulnerable to injury along its course. You need to connect: anatomical location of injury → nerve affected → motor/sensory deficit."
First Aid p. 450 (Upper extremity nerves) in the First Aid Guide: Focus On, the ELI5s, the video guide, Concept walkthrough, Key takeaways, How is this tested? and Test yourself.
First Aid p. 450 (Upper extremity nerves) in the First Aid Guide: Focus On, the ELI5s, the video guide, Concept walkthrough, Key takeaways, How is this tested? and Test yourself.

Want to see every block on a page opened up? Inside a First Aid Guide page →

Day 2 → first half of Day 3

Active reading: First Aid pp. 450–480 and 495–498

For every page you explain it, understand it and do it. You don't turn the page until all 3 are done.

1
Read Focus On for the page. Now you know what matters.
2
Run the Concept Walkthrough and the ELI5s. Explain each heading out loud. If you can't say it, you haven't understood it.
3
Read the actual First Aid page. It should now read like a summary of something you already know.
4
Solve the Test Yourself MCQs. Any miss → back to that heading before you turn the page.
Pace: 10–12 minutes a page, 4–6 pages an hour. 26 pages on Day 2, 9 on the morning of Day 3. Understanding is the only job. Memory is Day 4's job.

Day 2 · pp. 450–475 · anatomy, muscle, bone, injuries and joint disease (26 pages)

PagesTopic
450–454Upper limb nerves, rotator cuff, brachial plexus lesions, wrist and hand muscles, hand distortions, knee exam
455–458Hip muscles, lower limb nerves, ankle sprains, lumbosacral radiculopathy
459–462Muscle contraction, fibre types, smooth muscle, proprioceptors, bone formation, bone cell biology
462–467Elbow overuse, clavicle and wrist injuries, psoas abscess, knee conditions, childhood MSK conditions, paediatric fractures, achondroplasia, osteoporosis
468–471Osteopetrosis, osteomalacia and rickets, Paget disease, avascular necrosis, bone lab values, bone tumours
472–475Osteoarthritis vs rheumatoid arthritis, gout and pseudogout, Sjögren, septic arthritis, osteomyelitis, seronegative spondyloarthritis

Day 3, first half · pp. 476–480 + 495–498 · autoimmune disease and drugs (9 pages)

PagesTopic
476–480Lupus, polymyalgia, fibromyalgia, myositis, the vasculitides, NMJ diseases, Raynaud
495–498Arachidonic acid pathway, acetaminophen, aspirin and NSAIDs, bisphosphonates, gout drugs, teriparatide, TNF-α inhibitors and biologics
Skip pp. 481–494. That's dermatology. It gets its own block after MSK (see the end of this page).
🎬
A page still won't click? If the First Aid Guide page has a video, watch it first: the Guide puts the best video for the topic on the pages that need one. If it's still unclear, use 1 backup playlist, only for that topic: ▶Dirty Medicine · MSK/DermThe MSK videos only. Leave the derm ones for derm. ▶Ninja Nerd · Musculoskeletal/RheumatologyLong lectures. Use 1 video for 1 topic, not the playlist.
Day 3, second half → Day 4

Active application: Mehlman Medical

You understand MSK. Now learn how the exam asks it. Mehlman's videos take each high-yield topic and show you which clue rules an answer in and which one rules it out. In MSK that's the nerve-lesion and rheumatology questions, where 2 options look right until you know the 1 clue that separates them.

1
Videos, not PDFs. The value is the reasoning, and the PDFs don't have it.
2
The full MSK playlist, in order. Sort by date and watch the last 3 years first if you're short on time. The walkthrough on how to do this is in the University section of the Vault. Watch it first.
3
Pause before he answers. Answer it yourself. Any gap → open that First Aid Guide page and fix it the same day.
▶Mehlman Medical · Anatomy/MSK playlistYour active application step. In order, about 1 day.
Why: active reading gave you the facts. Active application turns facts into decisions, which is the only thing a UWorld question asks for. How to use Mehlman →
Day 4, second half

Active recall: FA Foundation Anki, MSK

The FA Foundation Anki deck is First Aid, page by page, 1 high-yield point per card, with the First Aid page number on every card. The MSK deck is 136 cards (as of October 2026): about 93 on the MSK pages and 43 on the derm pages.

1
Run the whole deck this afternoon, all 136 cards. The derm cards are an early pass; you run them again in the derm block. Answer before you flip. Recognising a line and pulling it out of memory are different skills, and UWorld tests the second one.
2
Hesitate → open the page. Go to that page number in the First Aid Guide, read the line and a couple above and below, then go back to the card.
A FA Foundation Anki card (renal shown), flipped: First Aid p. 597 on the card, and Study this in First Aid under the answer. The MSK deck works the same way.
A FA Foundation Anki card (renal shown), flipped: First Aid p. 597 on the card, and “Study this in First Aid” under the answer. The MSK deck works the same way.
Why: this is your third full pass of MSK First Aid, and the first one without the page in front of you. How to run the decks → · Open FA Foundation Anki in the Vault →

Run the FA Foundation Anki · MSK deck136 cards (as of October 2026), First Aid page by page, with the page number on every card. Opens straight into the deck.

Open the deck →
Days 5–6

UWorld MSK: the RPSR method

Now you open UWorld. You're not meeting MSK here. You're proving you already own it.

SettingChoose
QuestionsUnused
SubjectsAll
SystemsMusculoskeletal only (skin is a separate system; leave it for derm)
ModeTutor, untimed
Block size20 questions
S
Solve. 2 blocks of 20. Bookmark every question you got wrong and every one you got right by guessing.
R
Review in First Aid. For each bookmark, find the exact First Aid line it came from, highlight it, read a couple of lines around it. 5–6 minutes a question at most. Then the next 2 blocks.
▶How to Solve UWorldThe solve-and-review method on video. Written version: The RPSR Method.
Target: 65% or above. If your last 2 blocks are under 60%, go back to the Mehlman videos for those topics, then the First Aid pages behind them.
MSK is finished when every MSK question is attempted, every miss is traced to its First Aid page, and your last 2 blocks held above 65%. Not when a date passes. MSK has about 280 UWorld questions on the Vault schedule: 14 blocks, 6 a day on Days 5–6, and the last 2 the next morning. When is a system actually finished? → · The full RPSR method →

Later, for your NBMEs: NBME Booster Anki · MSKThe MSK questions from retired NBME forms 20 to 34 and the Free 120, as cards. Not for now: open it when your NBME phase starts. What the Booster is →

Open the Booster deck →

Then dermatology, separately

🩹
Derm is its own short block of 3 days, after MSK (the Vault schedule builds it in 3 days at 10–12 hours). First Aid pp. 481–494, 57 MCQs. Same order, smaller: the 7 derm organisms (Staphylococcus, Streptococcus, HSV, VZV, HPV, molluscum contagiosum, HHV-6) → active reading of pp. 481–494 → the Mehlman dermatology playlist → the derm Anki cards → UWorld skin. Open Derm Micro → ▶Mehlman Medical · Dermatology playlistActive application for derm.

Where MSK sits

MSK opens the neuro block: MSK, then psychiatry, then ANS, then neurology. They share pathways, drugs and anatomy, so done together they reinforce each other. MSK → psychiatry is a fixed order. Next: Psychiatry in 5 days → · later: Neurology in 7 days →

What not to do

Do not mix derm into MSK. 2 subjects in 1 week means neither sticks.
Do not open UWorld on Day 1. You'll score 40%, decide you're bad at MSK, and you're simply in the wrong order.
Do not read First Aid to memorise it. Days 2–3 are for understanding.
Do not skip the page MCQs. If you can't answer them, you read the page. You didn't learn it.
Read next.
→ The method behind every system: How to study any system.
→ The worked example, with every page free: Renal in 6 days.
→ What the Guide contains: What is the First Aid Guide.
→ Every system's micro and pharm lists: System guides.
→ Why you hit each page 5 ways instead of 1 perfect way: Perfectionist vs repetitionist.
Let the schedule place MSK for you.
Your exam date, your hours, every system in the right order. Renal is free to try first.
Open usmlevault.com/schedule →
usmlevault.com · free for your first 3 days
USMLE Vault · MSK in 6 Days · Created 2026-10-22 · All free guides
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