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USMLE Vault · Step 1 · Reproductive

Reproductive, start to finish, in 7 days

The system endocrine is built on. Get the hormones right here, and endo opens on familiar ground.

47 First Aid pages14 organisms235 MCQs7 days

By Dr. Marish Asudani · Published

How do I study reproductive for Step 1 in 7 days?

Give reproductive 7 days, not 6. Day 1: the 14 repro organisms. Day 2 to Day 3 morning: active reading of First Aid pp. 630–676 with the MCQs. Then the Mehlman repro playlist, the FA Foundation Anki repro deck, and UWorld repro on Days 5–7. Then endocrine.

Read this first

This is only for you if you have roughly 10–12 hours a day for studying, and you're an intern or a graduate.

Working, or studying 5–8 hours a day? Keep the same order and stretch the days. Step 1 while working →

It's 47 pages, from embryology to breast cancer to the prostate. That's why it gets the extra day, and it sets up the hormone story you'll need for endocrine, which comes right after it.

Repro first, endocrine second. That order is fixed on the schedule, and this page ends where the endocrine page begins.

Start here · before page 1

Reproductive: micro and pharm first

Repro starts with its own organisms: 14 organisms. Repro has no Pharm pill, because the drug map does not split out repro drugs, so its pharm is a check of the High-Yield Pharmacology PDF on Day 1 and the drug pages (pp. 673–676) on Day 3. These are the full guides.

Microbiology Pharmacology
Where this system sits

The order: easy systems first, cardio last

Reproductive is the 4th system, after the 3 easy ones (renal, respiratory, GI), and right before endocrine. Repro → endocrine is a fixed order. Cardio comes last. Tap a system to open its guide.

  1. 1Renal6 days · the easy one, start hereOpen →
  2. 2Respiratory6 days · same method as renalOpen →
  3. Before it: Biochem nutrition, 1 day, right before GI · where it sits
  4. 3GI7 daysOpen →
  5. 4Reproductive You are here7 daysOpen →
  6. Before it: Biochem carb and lipid metabolism, 1 day, right before endo · where it sits
  7. 5Endocrine6 daysOpen →
  8. 6Immunology5 daysOpen →
  9. Before it: Biochem cellular, molecular and amino acids, right before heme-onc · where it sits
  10. 7Heme-onc6 daysOpen →
  11. 8MSK6 days, no dermOpen →
  12. Before it: Dermatology, 3 days, after MSK · the derm block
  13. 9Psychiatry5 daysOpen →
  14. Before it: Genetics and ANS, right before neuro · genetics
  15. 10Neurology7 daysOpen →
  16. 11Cardiovascular7 days · always lastOpen →

Biochem is never a block of its own: each piece sits right before the system that needs it. The whole method, once: how to study any system →

1

The planRepro in 7 days, hour by hour

Repro runs in 1 fixed order. Here is every day, block by block.

Clock times assume an 11-hour day: 9 AM–1 PM, 2–6 PM and 7–10 PM, with lunch and dinner in the gaps. Shift the clock to your day. Keep the order.

Day 1 · Micro + the pharm checkA short day: 14 organisms
9–9:15 AMWatch How to do the Reproductive system, the University walkthrough.
9:15 AM–1 PMMicro: the 14 repro organisms, WRWRT. Watch, recall, watch the gaps, read the Sketchy PDF.
2–4 PMTest: the First Aid Guide MCQs for all 14 organisms. Any miss → that organism again.
4–5 PMPharm: open the High-Yield Pharmacology PDF and find any repro drugs. Any notes there, you do next to pp. 673–676 on Day 3. Day 1 ends here.
Day 2 · Active readingFirst Aid Guide, page by page, MCQs on every page
9 AM–1 PMpp. 630–641 · early embryology, teratogens, placenta, twinning, pharyngeal arches, genital embryology, sexual differentiation
2–6 PMpp. 642–654 · gonadal descent, anatomy and histology, Sertoli and Leydig cells, spermatogenesis, oestrogen, progesterone, the menstrual cycle, pregnancy, lactation, puberty
7–10 PMpp. 655–666 · sex chromosome disorders, placental disorders, ectopic and molar pregnancy, hypertension in pregnancy, vulvar and vaginal pathology, PCOS, endometriosis, ovarian tumours
Day 3 · Reading, then Mehlman
9 AM–1 PMpp. 667–676 · breast pathology, penile and testicular disorders, BPH, prostate cancer, then the repro drugs
2–6 PMWatch How to watch Mehlman Medical videos (10 minutes), then the Mehlman OB-GYN and repro playlist from the top, in order.
7–10 PMMehlman, continued. Pause before he answers and answer it yourself.
Day 4 · Mehlman, then Anki
9 AM–1 PMFinish the Mehlman repro playlist. Any gap → that First Aid Guide page, the same day.
2–6 PMFA Foundation Anki · Reproductive, 205 cards. Answer before you flip.
7–9 PMFinish the deck. Then open the First Aid page of every card you hesitated on.
Day 5 · UWorld reproUnused · reproductive only · tutor mode · 20 questions a block
9–9:30 AMClear today's due FA Foundation Anki cards first.
9:30 AM–1 PMBlocks 1–2 (Qs 1–40): solve both in tutor mode, log each score, then review every bookmark in First Aid.
2–6 PMBlock 3 (Qs 41–60): solve in tutor mode, log the score, then review every bookmark in First Aid.
7–10 PMRe-read every First Aid line you highlighted today.
Day 6 · UWorld repro
9–9:30 AMClear today's due FA Foundation Anki cards first.
9:30 AM–1 PMBlocks 4–5 (Qs 61–100): solve both in tutor mode, log each score, then review every bookmark in First Aid.
2–6 PMBlock 6 (Qs 101–120): solve in tutor mode, log the score, then review every bookmark in First Aid.
7–10 PMRe-read every First Aid line you highlighted today.
Day 7 · UWorld repro + Anki revisionThe last 2 blocks, then the finish check
9–9:30 AMClear today's due FA Foundation Anki cards first.
9:30 AM–1 PMBlocks 7–8 (Qs 121–160): solve both in tutor mode, log each score, then review every bookmark in First Aid.
2–6 PMFA Foundation Anki revision: the repro cards you missed on Day 4. Then check the 3 finish rules below.
Same pages, 5 angles. Micro, then active reading, then active application, then active recall, then UWorld. Every step hits the same 47 First Aid pages from a different direction. The method behind every system →

Want a day-by-day schedule that tells you exactly what to study next? The Vault builds it around your exam date.

USMLE Vault day-by-day schedule Build my schedule →
2

Day 1Micro of repro, from the pill

Open the First Aid Guide → Reproductive in the Vault (what the First Aid Guide is) and tap the Micro pill. It opens the exact repro list, and nothing else.

Reproductive in the First Aid Guide on usmlevault.com: its First Aid pages, MCQ count, the micro and pharm pills it has, and the How to do Reproductive video.
Reproductive in the First Aid Guide on usmlevault.com: its First Aid pages, MCQ count, the micro and pharm pills it has, and the How to do Reproductive video.

Micro · 14 organisms · the WRWRT method. Watch the sketch at 1x with no notes → Recall the whole story in your head, in order → Watch again only the gaps at 1.5–1.75x → Read the Sketchy PDF for that organism → Test with the First Aid Guide MCQs for that organism.

Bacteria · 7N. gonorrhoeaeC. trachomatisT. pallidumH. ducreyiGardnerellaE. coliS. agalactiae (Group B)Viruses · 5HPVHSVHIVCMVHepatitis BParasites · 1Trichomonas vaginalisFungi · 1Candida albicans

Open Repro Micro → · The Sketchy Micro guide →

▶How to do Sketchy MicroThe efficient method, 15 minutes.

Pharm: Reproductive has no Pharm pill, because the drug map does not split out reproductive drugs. Before you start reading, open the High-Yield Pharmacology PDF and look for any reproductive drugs. If there are notes, do them next to the drug pages (pp. 673–676) when you reach them, not saved for later. The drugs make more sense next to the disease.

Never done Sketchy? Do the same list from First Aid and the First Aid Guide alone. The list does not change, only the source. Every system's micro and pharm →
Why micro first: when you reach the vulvar and vaginal pathology on pp. 661–662 and the testicular infections on p. 671, the organisms are old friends, not new facts.
3

Before Day 2What the First Aid Guide is, and why you read it

First Aid was written to remind you, not to teach you. Every line assumes you already understand it. That is why IMGs spend 3 hours on 1 page, Google half of it, and still remember nothing a week later.

The First Aid Guide on usmlevault.com puts the teaching back into the page. Every reproductive page (pp. 630–676) has the same 5 parts:

Example: p. 664, Ovarian tumours.

Focus On tells you what matters on this page: the tumour markers (AFP for yolk sac tumour, hCG and LDH for dysgerminoma), serous carcinoma as the most common malignant ovarian tumour, and the dermoid cyst (mature teratoma) as the most common in young women.

First Aid p. 664 (Ovarian tumors) in the First Aid Guide: Focus On, the ELI5s, the video guide, Concept walkthrough, Key takeaways, How is this tested? and Test yourself.
First Aid p. 664 (Ovarian tumors) in the First Aid Guide: Focus On, the ELI5s, the video guide, Concept walkthrough, Key takeaways, How is this tested? and Test yourself.
Why it works: you understand the page, then prove it with MCQs in the same minute. 60–70% of UWorld traces straight back to First Aid lines, so a page you truly understood is a UWorld question you already own.

Open Reproductive in the First Aid GuideFirst Aid pp. 630–676, page by page: Focus On, ELI5 and the MCQs on every page. Opens straight into reproductive.

Open Reproductive →
▶How to use the First Aid GuideWatch once, before your first page.
4

Day 2 → Day 3 morningActive reading: First Aid pp. 630–676

Active reading means that for every page you explain it, understand it, and do it. The MCQs are part of the reading. That is what makes it active. You do not move to the next page until all 3 are done.

  1. Read Focus On for the page. Now you know what matters.
  2. Run the Concept Walkthrough and the ELI5s. Explain each heading back in your own words, out loud. If you cannot say it, you have not understood it.
  3. Read the actual First Aid page. It should now read like a summary of something you already know.
  4. Solve the Test Yourself MCQs. Any miss → back to that heading before you turn the page.
Pace: 10–12 minutes a page, 4–6 pages an hour. Do not memorise. Understanding is the only job on these pages. Memory is the Anki step's job.
Day 2 · pp. 630–660 · embryology to pregnancy disorders (31 pages)
630–633Early embryonic development, derivatives, teratogens, fetal alcohol syndrome
634–641Placenta, twinning, umbilical cord, pharyngeal arches, clefts, genital embryology, sexual differentiation
642–646Gonadal descent, female and male anatomy, histology, Sertoli and Leydig cells
647–654Spermatogenesis, oestrogen and progesterone, the menstrual cycle, pregnancy, hCG, lactation, puberty
655–660Sex chromosome disorders, AIS, placental disorders, ectopic and molar pregnancy, hypertension in pregnancy
Day 3 morning · pp. 661–676 (16 pages)
661–666Vulvar and vaginal pathology, PCOS, endometriosis, leiomyoma, ovarian tumours, uterine conditions
667–672Breast pathology and cancer, penile and testicular disorders, testicular tumours, BPH, prostate cancer
673–676Hormone control, GnRH analogs, SERMs, aromatase inhibitors, contraception, tocolytics, antiandrogens
If a page still won't clickDirty Medicine · Reproductive →Ninja Nerd · Reproductive →Watch only the video for the page you are stuck on, then go back to the page. These are a backup, not a step.
5

Day 3 afternoon → Day 4 morningActive application: Mehlman Medical

You understand repro. Now you learn how the exam asks it. Mehlman's videos take each high-yield topic and show you which clue rules an answer in, which one rules it out, and how to get from the stem to the answer.

  1. Videos, not PDFs. The value is the reasoning, and the PDFs do not have it.
  2. The full repro playlist, in order. Not random clips. Watch the how-to video below first.
  3. Pause before he answers, and answer it yourself. Anything that exposes a gap → open that First Aid Guide page and fix it the same day.
  4. Short on time? Sort the playlist by date and watch the last 3 years first.
▶Mehlman Medical · Obgyn/repro playlistWatch in order. This is the step. ▶How to watch Mehlman Medical videosWatch this before the playlist, 10 minutes.
Why: active reading gave you the facts. Active application turns facts into decisions, and a decision is the only thing a UWorld question asks for. How to use Mehlman →
6

Day 4 afternoonActive recall: FA Foundation Anki

What it is: the FA Foundation Anki deck is First Aid, page by page. 1 high-yield point per card, and the First Aid page number is on every card. The Reproductive deck is 205 cards (as of October 2026).

How to use it: run the whole repro deck in this half day. Answer before you flip. If you hesitate, open that page in the First Aid Guide, read the line plus a couple of lines above and below, then go back to the card.

Why: this is your third full pass of repro First Aid, and the first one done without the page in front of you. Recognising a line and pulling it out of memory are different skills, and UWorld tests the second one.

Example card · FA Foundation Anki · ReproductiveA 19-year-old woman has a 12 cm ovarian mass containing hair, teeth and sebaceous material, with tissue from all 3 germ layers.
What is true about this tumour?
It is the most common ovarian tumour in young women: a mature cystic teratoma (dermoid cyst), benign, with tissue from ectoderm, mesoderm and endoderm.
First Aid p. 664
▶How to do Anki from the First Aid GuideHow to run the FA Foundation Anki cards, 10 minutes.

On the UWorld days, keep the deck running: clear the cards that are due before your first block each morning. How to run the decks → · Open FA Foundation Anki in the Vault →

Run the FA Foundation Anki · Reproductive deck205 cards (as of October 2026), First Aid page by page, with the page number on every card. Opens straight into the deck.

Open the deck →
7

Days 5–7UWorld repro: the RPSR method

Now you open UWorld. You are not meeting repro here. You are proving you already own it.

UWorld settings
QuestionsUnused
SubjectsAll
SystemsReproductive only
ModeTutor, untimed
Block20 questions
  1. Solve. Do 2 blocks of 20. Bookmark every question you got wrong and every one you got right by guessing.
  2. Review in First Aid. For each bookmark, find the exact First Aid line it came from, highlight it, and read a couple of lines around it. 5–6 minutes a question, no more. Then the next 2 blocks.
Target: 65% or above. If your last 2 blocks are under 60%, go back to the Mehlman videos for those topics, then the First Aid pages behind them.

Reproductive has about 160 UWorld questions on the USMLE Vault schedule: 8 blocks over Days 5–7 (the plan above). Keep going until the 3 checks below are true.

Reproductive is finished when every repro UWorld question is attempted, every miss is traced to its First Aid page, and your last 2 blocks held above 65%. Not when a date passes. When is a system actually finished? →

Later, for your NBMEs: NBME Booster Anki · ReproductiveThe reproductive questions from retired NBME forms 20 to 34 and the Free 120, as cards. Not for now: open it when your NBME phase starts. What the Booster is →

Open the Booster deck →
▶How to solve UWorld and Amboss questionsWatch before your first block, 20 minutes.

The full method: The RPSR Method →

What not to do

Do not open UWorld on Day 1. You will score 40%, decide you are bad at repro, and you are simply in the wrong order.
Do not read First Aid to memorise it. The reading days are for understanding. Memory is the Anki step's job.
Do not skip the page MCQs. If you cannot answer them, you read the page. You did not learn it.
Do not split repro across weeks. 7 days in a row. A half-done system behaves like an undone one.
What comes next: endocrine. Repro → Endocrine is a fixed order on the schedule. After repro, take 1 day for carbohydrate and lipid metabolism, then start endocrine with the insulin pharmacology. Endocrine in 6 days →
Repro, then endocrine. The schedule keeps the order for you.
Enter your exam date and your hours. The schedule builds every system, day by day, with the right pages on each day.
Open usmlevault.com/schedule →
usmlevault.com · Renal is free · free for your first 3 days
Read next

Endocrine in 6 days — what comes right after repro.

GI in 7 days — what comes right before it.

How to study any system — the method every system page uses.

The RPSR Method — how to solve and review UWorld.

When is a system actually finished? — the checks before you move on.

USMLE Vault · Reproductive, start to finish, in 7 days · Created 2026-10-22 · All free guides
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